Studies on Application of Wax Matrix System for Controlled Drug Release.

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Release from or through a wax matrix system. I. Basic release properties of the wax matrix system.

Release properties from a wax matrix tablet was examined. To obtain basic release properties, the wax matrix tablet was prepared from a physical mixture of drug and wax powder (hydrogenated caster oil) at a fixed mixing ratio. Properties of release from the single flat-faced surface or curved side surface of the wax matrix tablet were examined. The applicability of the square-root time law and ...

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Matrix Tablets: An Effective Way for Oral Controlled Release Drug Delivery

       The purpose of this review article is to characterize all of the parameters regarding the types, polymers used, and release kinetics of matrix tablets. Matrix system was the earliest oral extended release platform for medicinal use. Matrix tablets are most commonly used methods to modulate the release profile of drugs. They are much desirable and preferred for such therapy because they o...

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Release from or through a wax matrix system. III. Basic properties of release through the wax matrix layer.

Release property of reservoir device matrix tablet was examined. Wax matrix layer was prepared from physical mixture of lactose and hydrogenated castor oil to obtain basic release properties. Release process showed zero order kinetics in a steady state after a given lag times, and could be divided into two stages. The first stage was the formation process of water channel by dissolving the solu...

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Release from or through a wax matrix system. II. Basic properties of release from or through the wax matrix layer.

In order to examine basic properties of release from and through wax matrix layer, reservoir device matrix tablet was prepared from a physical mixture of hydrogenated caster oil and drug that was the same one in the reservoir. Release process could be divided into two stages. The first stage was the formation process of water channel by dissolving the drug in the wax matrix layer, and dissolved...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 1993

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.41.586